SKF-82958 hydrobromide ((±)-SKF 82958 hydrobromide)

A dopamine D1 receptor agonist

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库存: 现货

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5mg

￥1075.00

860.00

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10mg

￥1712.00

1370.00

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25mg

￥3450.00

2760.00

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50mg

￥6200.00

4960.00

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100mg

￥11237.00

8990.00

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货号: ajce51570
CAS: 74115-01-8
别名: (±)-SKF-82958 hydrobromide; Chloro-APB hydrobromide
分子式: C19H21BrClNO2
分子量: 410.73
纯度: >98%
溶解度: DMSO : ≥ 102.5 mg/mL (249.56 mM)
储存: Store at -20°C
库存: 现货

Background

SKF 82958 is a dopamine D₁ receptor agonist (K_0.5 = 4 nM in a radioligand binding assay).¹ It is selective for dopamine D₁ over D₂ receptors (K_0.5 = 73 nM). SKF 82958 induces dopamine D₁ receptor-dependent adenylate cyclase activity in rat striatal membranes (EC₅₀ = 491 nM). SKF 82958 (3 mg/kg) prevents and reverses fentanyl-induced respiratory depression, without affecting analgesia, in cats.² It also increases locomotion and rearing in rats.³

1.Mottola, D.M., Laiter, S., Watts, V.J., et al.Conformational analysis of D1 dopamine receptor agonists: Pharmacophore assessment and receptor mappingJ. Med. Chem.39(1)285-296(1996) 2.Lalley, P.M.D1-dopamine receptor agonists prevent and reverse opiate depression of breathing but not antinociception in the catAm. J. Physiol. Regul. Integr. Comp. Physiol.289(1)R45-R51(2005) 3.Swanson, C.J., Heath, S., Stratford, T.R., et al.Differential behavioral responses to dopaminergic stimulation of nucleus accumbens subregions in the ratPharmacol. Biochem. Behav.58(4)933-945(1997)