A β-lactam antibiotic
Flucloxacillin is a β-lactam antibiotic.1 It is active against clinical isolates of S. aureus (MICs = 0.12-0.25 mg/L). Flucloxacillin (42.3 mg/kg every six hours) decreases vegetation titers in a rat model of aortic valve endocarditis induced by S. aureus. Formulations containing flucloxacillin have been used in the treatment of bacterial infections.
1.Entenza, J.M., Vouillamoz, J., Glauser, M.P., et al.Levofloxacin versus ciprofloxacin, flucloxacillin, or vancomycin for treatment of experimental endocarditis due to methicillin-susceptible or -resistant Staphylococcus aureusAntimicrob. Agents Chemother.41(8)1662-1667(1997)
|
Animal experiment: |
Rats: On the day of the experiment the animal is given an intravenous bolus injection of 200 mg/kg as pure free acid sodium flucloxacillin (dose volume: 1 mL sterile water per kg) and then return to the metabolism cage. Urine is collected directly into individual CO2 cooled containers for a period of 24 h before dosing and then at frequent intervals after dosing[3]. |
|
参考文献: [1]. Paton DM, et al. Bioavailability and half-life of two preparations of flucloxacillin. N Z Med J. 1982 Nov 10;95(719):766-8. |
|
动态评分
0.0