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  • Tetrahydrocoptisine ((RS)-Stylopine)
Tetrahydrocoptisine ((RS)-Stylopine)的可视化放大

Tetrahydrocoptisine ((RS)-Stylopine)

An alkaloid with anti-inflammatory and antioxidant activities

原价
¥1087-1937
价格
870-1550
Tetrahydrocoptisine ((RS)-Stylopine)的二维码

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  • 货号: ajce51996
  • CAS: 4312-32-7
  • 别名: 四氢黄连碱; Tetrahydrocoptisine
  • 分子式: C19H17NO4
  • 分子量: 323.34
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Tetrahydrocoptisine is an alkaloid that has been found in C. impatiens and has anti-inflammatory and antioxidant activities.1,2 It inhibits LPS-induced NF-κB activation and production of nitric oxide (NO), TNF-α, and IL-6 in isolated mouse peritoneal macrophages when used at concentrations ranging from 0.001 to 1 ?g/ml.1 Tetrahydrocoptisine (10 and 30 mg/kg) inhibits xylene-induced ear edema in mice, and it decreases serum levels of TNF-α in a mouse model of LPS-induced septic shock. It reduces the severity of ethanol-induced gastric ulcers in mice when administered at doses of 10 or 20 mg/kg.2


1.Li, W., Huang, H., Zhang, Y., et al.Anti-inflammatory effect of tetrahydrocoptisine from Corydalis impatiens is a function of possible inhibition of TNF-α, IL-6 and NO production in lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-κB activation and MAPK pathwayEur. J. Pharmacol.715(1-3)62-71(2013) 2.Li, W., Huang, H., Niu, X., et al.Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in miceToxicol. Appl. Pharmacol.272(1)21-29(2013)

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