A hepatitis C virus NS5A inhibitor
Ombitasvir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A).1,2 It reduces HCV replication in stable replicon cell lines with EC50 values ranging from 0.82 to 19.3 pM against genotypes 1a, 1b, 2a, 2b, 3a, 4a, and 5a and an EC50 value of 366 pM for genotype 6a.1,2 Against subgenomic replicons from clinical isolates of genotypes 1a-6a expressed in Huh-7 derived cells, ombitasvir inhibits HCV replication with EC50 values ranging from 0.1 pM for genotype 4a to 68 pM for genotype 6a.2 Formulations containing ombitasvir have been used in the treatment of HCV genotypes 1 and 4.
1.Zhang, X.Direct anti-HCV agentsActa Pharmaceutica Sinica B6(1)26-31(2015) 2.Krishnan, P., Beyer, J., Mistry, N., et al.In vitro and in vivo antiviral activity and resistance profile of ombitasvir, an inhibitor of hepatitis C virus NS5AAntimicrob. Agents Chemother.59(2)979-987(2015)
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