DCVC

DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine) 是三氯乙烯 (TCE) 的生物活性代谢物。

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库存: 现货

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5mg

￥3737.00

2990.00

- +
10mg

￥5350.00

4280.00

- +
50mg

￥15887.00

12710.00

- +
100mg

￥22250.00

17800.00

- +

已选 0 种 0 瓶

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货号: ajce52110
CAS: 13419-46-0
别名: S-[(1E)-1,2-dichloroethenyl]--L-cysteine
分子式: C5H7Cl2NO2S
分子量: 216.09
纯度: >98%
溶解度: DMSO : 23 mg/mL (106.44 mM);Water : 1.034 mg/mL (4.79 mM)
储存: Store at -20°C
库存: 现货

Background

DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.Target: TNF-αin vitro: DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. DCVC effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue punch cultures of extraplacental membranes. DCVC effects on GBS-stimulated release of pro-inflammatory cytokines from extraplacental membranes in transwell cultures.

[1]. Boldenow E, et al. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α in human extraplacental membranes in vitro. Reprod Toxicol. 2015 Apr;52:1-6. [2]. Lash LH, et al. Multigenerational study of chemically induced cytotoxicity and proliferation in cultures of human proximal tubular cells. Int J Mol Sci. 2014 Nov 18;15(11):21348-65. [3]. Yoo HS, et al. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. J Toxicol Environ Health A. 2015;78(1):32-49.