ABT-072

ABT-072是非核苷NS5Bpolymerase的抑制剂，为治疗HCV的有效候选药。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥2475.00

1980.00

- +
5mg

￥4837.00

3870.00

- +
10mg

￥8637.00

6910.00

- +
20mg

￥14812.00

11850.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

ABT-072 is a nonnucleoside NS5B polymerase inhibitor and a candidate drug evaluated for treatment of hepatitis C virus.

ABT-072 inhibits non-nucleoside NS5B polymerase, and yields antiviral effects[1].

[1]. Min Gao, et al. Combinations of Hepatitis C Virus Inhibitors. US 20120196794 A1

Protocol

Cell experiment:

To determine compound efficacy, HCV replicon cells are plated at a density of 104 per well in 96-well plates in DMEM media containing 10% FBS. Following incubation overnight, compounds serially diluted in DMSO, or DMSO alone, are added to individual wells to a final DMSO concentration of 0.5%. Cell plates are then incubated at 37°C. for 3 days prior to assaying for cytotoxicity and HCV inhibition. Cell viability is measured using an Alamar Blue assay and CC50 values are calculated using the median effect equation.

参考文献:

[1]. Min Gao, et al. Combinations of Hepatitis C Virus Inhibitors. US 20120196794 A1