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  • Zanubrutinib (BGB-3111)
Zanubrutinib (BGB-3111)的可视化放大

Zanubrutinib (BGB-3111)

A potent and covalent BTK inhibitor

原价
¥1962-11062
价格
1570-8850
Zanubrutinib (BGB-3111)的二维码

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  • 货号: ajce52392
  • CAS: 1691249-45-2
  • 别名: 泽布替尼; BGB-3111
  • 分子式: C27H29N5O3
  • 分子量: 471.55
  • 纯度: >98%
  • 溶解度: DMSO : ≥ 56.75 mg/mL (120.35 mM);Ethanol : < 1 mg/mL (insoluble)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Zanubrutinib is a potent and covalent inhibitor of Bruton's tyrosine kinase (BTK; IC50 = 0.3 nM).1 It is selective for BTK over a panel of 304 kinases at 1 μM but does inhibit EGFR, Tec, Blk, BMX, HER4, and TXK (IC50s = 0.62-33 nM). Zanubrutinib inhibits phosphorylation of BTK at Y233 (IC50 = 1.8 nM) in Ramos cells and reduces viability of REC-1 cells (IC50 = 0.36 nM). In vivo, zanubrutinib (2.5 and 7.5 mg/kg) reduces tumor volume in an OCI-LY10 diffuse large B cell lymphoma (DLBCL) mouse xenograft model.


1.Guo, Y., Liu, Y., Hu, N., et al.Discovery of zanubrutinib (BGB-3111), a novel, potent, and selective covalent inhibitor of bruton's tyrosine kinaseJ. Med. Chem.62(17)7923-7940(2019)

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