SMER18
SMER18是Rapamycin的一种小分子增强剂,充当mTOR非依赖性的的自噬诱导剂。
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包装价格促销价数量
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2mg￥2512.002010.00- +
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5mg￥3737.002990.00- +
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10mg￥5350.004280.00- +
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50mg￥15887.0012710.00- +
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100mg￥22250.0017800.00- +
- 货号: ajce52476
- CAS: 944153-47-3
- 别名:
- 分子式: C16H14ClNO2
- 分子量: 287.74
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.Target: mTORSMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models, which suggests therapeutic potential.
[1]. Sarkar S, et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 Jun;3(6):331-338.
