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DC1是DNA小沟结合的烷基化酶CC-1065的类似物,是可用于靶向治疗癌症的细胞毒性DNA烷基化酶的抗体偶联物。
DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer.
[1]. Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66(6):3214-21.
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