H-151

A STING inhibitor

原价

￥675-6300

价格

￥ 540-5040

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库存: 现货

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产品引用

货号: ajce53462
CAS: 941987-60-6
别名:
分子式: C17H17N3O
分子量: 279.34
纯度: >98%
溶解度: DMSO : 125 mg/mL (447.48 mM);Water : < 0.1 mg/mL (insoluble)
储存: Store at -20°C
库存: 现货

Background

H-151 is an inhibitor of stimulator of interferon genes (STING).¹ It forms an adduct with mouse STING in serum and acts in an irreversible manner. It inhibits the type I interferon (IFN) response and reduces the phosphorylation of TBK1 and palmitoylation of human STING (hsSTING) in vitro. It also reduces increases in mouse serum levels of IFN-β and IL-6 induced by the STING agonist 10-carboxymethyl-9-acridanone (CMA).

1.Haag, S.M., Gulen, M.F., Reymond, L., et al.Targeting STING with covalent small-molecule inhibitorsNature559(7713)269-273(2018)

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信号通路

生命科学

有机化学

无机化学

材料科学

H-151

H-151详情

Background