LMP7-IN-1|2285330-15-4|安捷凯

LMP7-IN-1

LMP7-IN-1 是一种可口服的、有效的、可逆的和高度选择性的免疫蛋白酶体亚基 LMP7 (β5i) 抑制剂。 LMP7-IN-1 对 LMP7 亚基具有高生化 (IC50=3.6 nM) 和细胞 (IC50=3.4 nM) 效力。 LMP7-IN-1 在多发性骨髓瘤异种移植模型中显示出强大的抗肿瘤功效。 LMP7-IN-1 可显着长期抑制肿瘤 LMP7 活性和泛素化蛋白转换，并诱导多发性骨髓瘤细胞凋亡。

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Background

LMP7-IN-1 is an inhibitor of immunoproteasome (LMP7), may used in the research of inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases and cancer[1]. LMP7[1]

LMP7-IN-1 (Example 2) is an inhibitor of immunoproteasome (LMP7), may used in the research of inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases and cancer[1].

[1]. Markus Klein, et al. Boronic acid derivatives. WO2019038250A1.