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PROTAC Sirt2-binding moiety 1 是一种选择性和高效的 Sirtuin 2 (Sirt2) 抑制剂,IC50 为 2.4 μM. PROTAC Sirt2 结合部分 1,基于 SirReal1 的部分,通过接头与 cereblon 配体结合形成 PROTAC 以降解 Sirt2。
PROTAC Sirt2-binding moiety 1 is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. For the development of sirtuin rearranging ligands (SirReals)-based PROTAC[1]. IC50: 2.4 μM (Sirt2)[1].
[1]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.
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