An inhibitor of MAO-A
Toloxatone is an inhibitor of monoamine oxidase A (MAO-A; Ki = 1.8 ?M).1 It is selective for MAO-A over MAO-B (Ki = 44 ?M). Toloxatone (100 mg/kg) inhibits deamination of serotonin (5-HT) and norepinephrine in rat brain.2 It also decreases immobility time in the forced swim test in mice when administered at a dose of 256 mg/kg.3
1.Cesura, A.M., and Pletscher, A.The new generation of monoamine oxidase inhibitorsProg. Drug Res.38171-297(1992) 2.Keane, P.E., Kan, J.P., Sontag, N., et al.Monoamine oxidase inhibition and brain amine metabolism after oral treatment with toloxatone in the ratJ. Pharm. Pharmacol.31(11)752-754(1979) 3.Van der Meersch-Mougeot, V., da Rocha, M., Jr., Monier, C., et al.Benzodiazepines reverse the anti-immobility effect of antidepressants in the forced swimming test in miceNeuropharmacology32(5)439-446(1993)
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