24R-Calcipotriol（PRI 2202，卡泊三醇杂质D）
24R-Calcipotriol(PRI 2202)是钙泊三醇的杂质，钙泊三醇是1,25-Dihydroxyvitamin D3类似物。
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包装价格促销价数量
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10mg￥0.000.00- +
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5mg￥0.000.00- +
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1mg￥4738.004264.00- +
- 货号: ajce54402
- CAS: 112827-99-3
- 别名: 24R-卡泊三醇,PRI 2202; Impurity D of Calcipotriol
- 分子式: C27H40O3
- 分子量: 412.6
- 纯度: ＞98%
- 溶解度: DMSO: ≥ 100 mg/mL (242.37 mM)
- 储存: -20°C, protect from light, stored under nitrogen,unstable in solution, ready to use.
- 库存: 现货
Background
24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.IC50 value:Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.
[1]. Gocek, Elzbieta; Kielbinski, Marek; Baurska, Hanna et al. Different susceptibilities to 1,25-dihydroxyvitamin D3-induced differentiation of AML cells carrying various mutations. Leukemia Research (2010), 34(5), 649-657. [2]. Gocek, Elzbieta; Kielbinski, Marek; Wylob, Paulina et al. Side-chain modified vitamin D analogs induce rapid accumulation of VDR in the cell nuclei proportionately to their differentiation-inducing potential. Steroids (2008), 73(14), 1359-1366. [3]. Wietrzyk, Joanna; Nevozhay, Dmitry; Filip, Beata et al. The antitumor effect of lowered doses of cytostatics combined with new analogs of vitamin D in mice. Anticancer Research (2007), 27(5A), 3387-3398. [4]. Wietrzyk, Joanna; Chodynski, Michal; Fitak, Hanna et al. Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anti-Cancer Drugs (2007), 18(4), 447-457.
