3-O-Acetyloleanolic acid
A triterpene with diverse biological activities
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包装价格促销价数量
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1mg￥0.000.00- +
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5mg￥3612.002890.00- +
- 货号: ajce54440
- CAS: 4339-72-4
- 别名: 齐墩果酸3-乙酸酯
- 分子式: C32H50O4
- 分子量: 498.74
- 纯度: ＞98%
- 溶解度: DMF: 0.14mg/mL
- 储存: Store at -20°C
- 库存: 现货
Background
Oleanolic acid acetate is a triterpene that has been found in the root bark of M. macrophylla and has diverse biological activities.1,2,3,4 It is active against P. gingivalis (MIC = 39 ?g/ml).1 Oleanolic acid acetate (5-50 ?M) induces apoptosis in and reduces viability of HCT116 colon carcinoma cells.2 It induces apoptosis in human umbilical vein endothelial cells (HUVECs) in vitro and inhibits capillary vessel formation in a Matrigel? plug assay in mice.3 Oleanolic acid acetate (2, 10, and 50 mg/kg) reduces the number of skin lesions, epidermal thickness and immune cell infiltration, and serum IgE, IgG2a, and histamine levels in a mouse model of atopic dermatitis.4
1.Kim, N.-C., Desjardins, A.E., Wu, C.D., et al.Activity of triterpenoid glycosides from the root bark of Mussaenda macrophylla against two oral pathogensJ. Nat. Prod.62(10)1379-1384(1999) 2.Yoo, K.H., Park, J.-H., Cui, E.J., et al.3-O-acetyloleanolic acid induces apoptosis in human colon carcinoma HCT-116 cellsPhytother. Res.26(10)1541-1546(2012) 3.Cui, E.-J., Hwang-Bo, J., Park, J.-H., et al.3-O-Acetyloleanolic acid exhibits anti-angiogenic effects and induces apoptosis in human umbilical vein endothelial cellsBiotechnol. Lett.35(11)1807-1815(2013) 4.Choi, J.K., Oh, H.-M., Lee, S., et al.Oleanolic acid acetate inhibits atopic dermatitis and allergic contact dermatitis in a murine modelToxicol. Appl. Pharmacol.269(1)72-80(2013)
