4-Hydroxycoumarin

A coumarin

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1mg

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5mg

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Background

4-Hydroxycoumarin is a coumarin that has been found in C. corniculatus.¹ It inhibits vitamin K₁ epoxidation and prothrombin synthesis by 18 and 67%, respectively, in cell-free assays when used at a concentration of 6.2 mM.² 4-Hydroxycoumarin has been used in the synthesis of anticoagulants, as well as antithrombotic, anti-inflammatory, antibacterial, and antifungal agents.^3,4

1.Vickery, M., and Vickery, B.Coumarins and related compounds in members of the ConnaraceaeToxicol. Lett.5(2)115-118(1980) 2.Bell, R.G., and Stark, P.Inhibition of prothrombin synthesis and epoxidation of vitamin K1 by anticoagulants in vitroBiochem. Biophys. Res. Commun.72(2)619-625(1976) 3.Jung, J.-C., and Park, O.-S.Synthetic approaches and biological activities of 4-hydroxycoumarin derivativesMolecules14(11)4790-4803(2009) 4.Chohan, Z.H., Shaikh, A.U., Rauf, A., et al.Antibacterial, antifungal and cytotoxic properties of novel N-substituted sulfonamides from 4-hydroxycoumarinJ. Enzyme Inhib. Med. Chem.21(6)741-748(2006)