6-Thioinosine

6-?Thioinosine (6TI) 是一种嘌呤抗代谢物，为抗脂肪形成剂，能够降低 PPAR γ 和 C/EBPα 及其目标基因 LPL，CD36，aP2 和 LXRα 的 mRNA 水平。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
10mg

￥1412.00

1130.00

- +
50mg

￥2400.00

1920.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajce54584
CAS: 574-25-4
别名: 6-疏基嘌呤核苷,6TI; 6-Mercaptopurine riboside
分子式: C10H12N4O4S
分子量: 284.29
纯度: >98%
溶解度: DMSO: 50 mg/mL (175.88 mM)
储存: Store at -20°C
库存: 现货

Background

6-?Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα[1][2].

[1]. Lee J, et al. Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR gamma through JNK-dependent upregulation of iNOS. Cell Mol Life Sci. 2010 Feb;67(3):467-81. [2]. Neubert D, et al. Interference of 6-mercaptopurine riboside, 6-methylmercaptopurine riboside and azathioprine with the morphogenetic differentiation of mouse extremities in vivo and in organ culture. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):93-105.