Aclacinomycin A hydrochloride
Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子，是第一个发现对 20S 蛋白酶体 (20S proteasome) 的CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效治疗血癌和实体肿瘤的蒽环类化疗药物。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
5mg￥3050.002440.00- +
-
10mg￥5175.004140.00- +
-
25mg￥10575.008460.00- +
-
50mg￥17100.0013680.00- +
-
100mg￥0.000.00- +
-
200mg￥0.000.00- +
- 货号: ajce54718
- CAS: 75443-99-1
- 别名: 盐酸阿柔比星; Aclarubicin hydrochloride
- 分子式: C42H54ClNO15
- 分子量: 848.33
- 纯度: ＞98%
- 溶解度: DMSO: ≥ 125 mg/mL (147.35 mM)
- 储存: 4°C, protect from light
- 库存: 现货
Background
Aclacinomycin A hydrochloride (Aclarubicin hydrochloride), a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome[1]. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II[2]. An effective anthracycline chemotherapeutic agent for hematologic cancers and solid tumors[3]. 20S proteasome[1].Topoisomerase I and II[2].
[1]. Isoe T, et al. Inhibition of different steps of the ubiquitin system by CDDP and aclarubicin. Biochim Biophys Acta. 1992 Sep 15;1117(2):131-5. [2]. Hajji N, et al. Induction of genotoxic and cytotoxic damage by aclarubicin, a dual topoisomerase inhibitor. Mutat Res. 2005 May 2;583(1):26-35. [3]. Iihoshi H, et al. Aclarubicin, an anthracycline anti-cancer drug, fluorescently contrasts mitochondria and reduces the oxygen consumption rate in living human cells. Toxicol Lett. 2017 Aug 5;277:109-114.
