A ribonucleoside
Allopurinol riboside is a ribonucleoside and a ribose-containing derivative of the xanthine oxidase inhibitor allopurinol .1 It inhibits the growth of Leishmania promastigotes and prevents amastigote maturation into the promastigote phase of the parasite life cycle in cell-free assays.2 Allopurinol riboside (239, 511, and 929 mg/kg per day) prevents mortality in mouse models of T. cruzi infection but does not eradicate the infection.1
1.Croft, S.L., and Neal, R.A.The effect of allopurinol ribonucleoside and formycin B on Trypanosoma cruzi infections in miceTrans. R. Soc. Trop. Med. Hyg.79(4)517-518(1985) 2.Nelson, D.J., LaFon, S.W., Tuttle, J.V., et al.Allopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation254(22)11544-11549(1979)
动态评分
0.0