A phenol glucoside with diverse biological activities
Androsin is a phenol glucoside that has been found in P. kurroa and has diverse biological activities.1,2,3 It is active against the bacteria S. aureus, S. epidermidis, P. aeruginosa, E. cloacae, K. pneumoniae, and E. coli (MICs = 0.6, 0.68, 0.97, 0.85, 1, and 1.08 mg/ml, respectively) and the fungi C. albicans, C. tropicalis, and C. glabrata (MICs = 1.85, 1.7, and 1.65 mg/ml, respectively).3 Androsin (10 mg/kg) inhibits bronchial obstruction in a guinea pig model of asthma induced by ovalbumin or platelet-activating factor (PAF).2
1.Stuppner, H., and Wagner, H.Minor iridoid and phenol glycosides of Picrorhiza kurrooaPlanta Med.55(5)467-469(1988) 2.Dorsch, W., Stuppner, H., Wagner, H., et al.Antiasthmatic effects of Picrorhiza kurroa: Androsin prevents allergen- and PAF-induced bronchial obstruction in guinea pigsInt. Arch. Allergy Appl. Immunol.95(2-3)128-133(1991) 3.Zajdel, S.M., Graikou, K., Sotiroudis, G., et al.Two new iridoids from selected Penstemon species - antimicrobial activityNat. Prod. Res.27(24)2263-2271(2013)
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