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- Asperuloside
Asperuloside
An iridoid glycoside with diverse biological activities
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包装价格促销价数量
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1mg￥0.000.00- +
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5mg￥762.00610.00- +
- 货号: ajce55064
- CAS: 14259-45-1
- 别名: 车叶草苷
- 分子式: C18H22O11
- 分子量: 414.36
- 纯度: ＞98%
- 溶解度: DMF: 5mg/mL,DMSO: 5mg/mL,Ethanol: 2mg/mL,PBS (pH 7.2): 3mg/mL
- 储存: 4°C, protect from light
- 库存: 现货
Background
Asperuloside is an iridoid glycoside that has been found in G. tunetanum and has diverse biological activities, including anti-angiogenic, anti-inflammatory, and anti-obesity properties.1,2,3 It reduces microvessel formation by 67% in a chick embryo chorioallantoic membrane assay when used at a concentration of 2 μg/egg.1 Asperuloside (20, 40, and 80 mg/L) inhibits LPS-induced increases in TNF-α, IL-1β, and IL-6 production in RAW 264.7 macrophages in a concentration-dependent manner.2 It reduces lung myeloperoxidase (MPO) activity and bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and IL-6 in a mouse model of LPS-induced acute lung injury when administered at doses of 20, 40, and 80 mg/kg. Dietary administration of asperuloside decreases body weight gain, white adipose tissue (WAT) weight, and the ratio of WAT weight to body weight in a high-fat diet-induced mouse model of metabolic syndrome.3
1.Camero, C.M., Germanò, M.P., Rapisarda, A., et al.Anti-angiogenic activity of iridoids from Galium tunetanumBraz. J. Pharmacognosy28(3)374-377(2018) 2.Qiu, J., Chi, G., Wu, Q., et al.Pretreatment with the compound asperuloside decreases acute lung injury via inhibiting MAPK and NF-κB signaling in a murine modelInt. Immunopharmacol.31109-115(2016) 3.Hirata, T., Kobayashi, T., Wada, A., et al.Anti-obesity compounds in green leaves of Eucommia ulmoidesBioorg. Med. Chem. Lett.21(6)1786-1791(2011)
