A triterpenoid saponin with diverse biological activities
Bacopasaponin C is a triterpenoid saponin originally isolated from B. monniera that has diverse biological activities.1,2,3 It inhibits the ATPase activity of P-glycoprotein (IC50 = 57.83 ?g/ml).4 Bacopasaponin C inhibits scopolamine-induced impairments in spatial memory in the Morris water maze and memory retrieval in the step-down test in mice when administered at a dose of 50 mg/kg.1 It also decreases the time mice spent immobile in the forced swim and tail suspension tests, indicating antidepressant-like activity.2 Bacopasaponin C reduces the spleen parasite load in a hamster model of leishmaniasis when administered as a free compound or in liposomal, niosomal, microencapsulated, or nanocapsulated forms.3
1.Zhou, Y., Peng, L., Zhang, W.-D., et al.Effect of triterpenoid saponins from Bacopa monniera on scopolamine-induced memory impairment in micePlanta Med.75(6)568-574(2009) 2.Zhou, Y., Shen, Y.-H., Zhang, C., et al.Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice modelsJ. Nat. Prod.70(4)652-655(2007) 3.Sinha, J., Raay, B., Das, N., et al.Bacopasaponin C: Critical evaluation of anti-leishmanial properties in various delivery modesDrug Deliv.9(1)55-62(2002) 4.Singh, R., Rachumallu, R., Bhateria, M., et al.In vitro effects of standardized extract of Bacopa monniera and its five individual active constituents on human P-glycoprotein activityXenobiotica45(8)741-749(2015)
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