Balsalazide sodium hydrate
A prodrug form of 5-ASA
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包装价格促销价数量
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250mg￥656.00525.00- +
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1g￥1125.00900.00- +
- 货号: ajce55174
- CAS: 150399-21-6
- 别名: 巴柳氮钠水合物; Balsalazide disodium dihydrate
- 分子式: C17H17N3Na2O8
- 分子量: 437.31
- 纯度: ＞98%
- 溶解度: DMSO : 125 mg/mL (285.84 mM; Need ultrasonic); H2O : 100 mg/mL (228.67 mM; Need ultrasonic)
- 储存: Store at -20°C
- 库存: 现货
Background
Balsalazide is a prodrug form of 5-aminosalicylic acid .1 It is cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA. Balsalazide (600 mg/kg per day) decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane, as well as decreases micro- and macroscopic colonic damage, in a rat model of colitis induced by 2,4-dinitrochlorobenzene (DNCB).2 Formulations containing balsalazide have been used in the treatment of ulcerative colitis.
1.Tursi, A.Balsalazide in treating colonic diseasesExpert Opin. Drug Metab. Toxicol.5(12)1555-1563(2009) 2.Lu, Y.-X., and Chen, X.-M.Effects of balsalazide on experimental colitis induced by 2,4-dinitrochlorobenzene in ratsZhongguo Xinyao Yu Linchuang Zazhi26(12)901-904(2007)
