CS-003 Free base
CS-003 Free base (CS-003)是一种三速激肽受体拮抗剂，对人神经激肽 (Neurokinin) NK1，NK2 和 NK3 受体具有高亲和力，Ki 值分别为 2.3 nM，0.54 nM 和 0.74 nM。CS-003 Free base (CS-003) 对与神经激肽有关的呼吸系统疾病具有治疗功效。
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包装价格促销价数量
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100mg￥0.000.00- +
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250mg￥0.000.00- +
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500mg￥0.000.00- +
- 货号: ajce55744
- CAS: 191672-52-3
- 别名:
- 分子式: C34H38Cl2N2O6S
- 分子量: 673.65
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
CS-003 Free base (CS-003), a triple tachykinin receptor antagonist, shows high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with Ki values of 2.3 nM, 0.54 nM and 0.74 nM, respectively. CS-003 Free base (CS-003) has therapeutic efficacy on respiratory diseases associated with neurokinins. NK1|2.3 nM (Ki)|NK2|0.54 nM (Ki)|NK3|0.74 nM (Ki)
CS-003 (0.01-10 μM; 24 hours) inhibits NK1, NK2 or NK3 induced inositol phosphate formation in a concentration-dependent manner with pA2 values of 8.7, 9.4 and 9.5 μM, respectively[1].
CS-003 (intravenous injection; 0.01-3.0 mg/kg; 5 min before neurokinin A/B/C injection) inhibits substance P-induced tracheal vascular hyperpermeability, neurokinin A- and neurokinin B-induced bronchoconstriction with ID50 values of 0.13, 0.040 and 0.063 mg/kg, respectively[1].
[1]. Tsuchida H, et al. Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses. Eur J Pharmacol. 2008 May 31;586(1-3):306-12.
