A glycerolipid precursor
Dihydroxyacetone phosphate is a precursor in the biosynthesis of glycerolipids.1 It is produced by the glycolytic enzyme fructose-1,6-bisphosphate aldolase or by isomerization of glyceraldehyde-3-phosphate by triosephosphate isomerase.2 Erythrocyte levels of dihydroxyacetone phosphate are increased in patients with triosephosphate isomerase deficiency, an inborn error of metabolism characterized by hemolytic anemia and progressive neurological dysfunction.3
1.Dodds, P.F., Gurr, M.I., and Brindley, D.N.The glycerol phosphate, dihydroxyacetone phosphate and monoacylglycerol pathways of glycerolipid synthesis in rat adipose-tissue homogenatesBiochem J.160(3)693-700(1976) 2.Miyazawa, H., Yamaguchi, Y., Sugiura, Y., et al.Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branchingDevelopment144(1)63-73(2017) 3.Orosz, F., Vértessy, B.G., Hollán, S., et al.Triosephosphate isomerase deficiency: Predictions and factsJ. Theor. Biol.182(3)437-447(1996)
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