D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt 是D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3) 的六钾盐。是一种第二信使。可刺激钙从内质网排出。
D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is the hexapotassium salt of D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3), which is a second messenger that stimulates the discharge of calcium from the endoplasmic reticulum.
Second messenger D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3) is served as an inositol phosphate derivative. The dissociation constant (KD) for Pr55Gag complexed with D-myo-Inositol 1,4,5-trisphosphate (an inositol with divalent phosphate groups and devoid of lipid groups) is 2170 μM. The binding affinities of D-myo-Inositol 1,4,5-trisphosphate (KD=568 μM) and 1,3,4,5-IP4 (KD=526 μM) for matrix (MA) are almost identical[1].
[1]. Anraku K, et al. Highly sensitive analysis of the interaction between HIV-1 Gag and phosphoinositide derivatives based on surface plasmon resonance. Biochemistry. 2010 Jun 29;49(25):5109-16.
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