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Donitriptan 是一种有效的高亲和力 5-HT1B/1D 受体激动剂,pKi 分别为 9.4 和 9.3。
Donitriptan is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively[1]. 5-HT1B Receptor|9.4 (pKi)|5-HT1D Receptor|9.3 (pKi)
[1]. Mu?oz-Islas E, et al. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149(1):82-91.
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