DS28120313
DS28120313 是一种口服型铁调素 (hepcidin) 生成抑制剂, IC50值为 0.093 μM。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
5mg￥2725.002180.00- +
-
10mg￥4312.003450.00- +
-
25mg￥9175.007340.00- +
-
50mg￥14425.0011540.00- +
已选
0
种
0
瓶
金额:
￥0.00
首页
收藏
- 货号: ajce56046
- CAS: 2146177-09-3
- 别名:
- 分子式: C16H17N5O2
- 分子量: 311.34
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM[1]. IC50: 0.093 μM (hepcidin production)[1]
DS28120313 (deliver orally; 30 mg/kg; 30 min before IL-6 administration) inhibits hepcidin production and reduces the blood hepcidin level in IL-6 induced acute inflammatory C57BL/6 mouse model[1].
[1]. Fukuda T, et al. Discovery of DS28120313 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4,6-disubstituted indazole derivatives. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5252-5257.
