An alkaloid with diverse biological activities
Epiberberine is an alkaloid that has been found in C. chinensis and has diverse biological activities.1,2,3 It inhibits the activities of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-secretase 1 (BACE1; IC50s = 1.07, 6.03, and 8.55 ?M, respectively).1 Epiberberine scavenges peroxynitrite radicals in a cell-free assay with an IC50 value of 16.83 ?M. It is cytotoxic to HepG2 hepatocellular carcinoma (HCC) cells when used at a concentration of 100 ?M.2 Epiberberine (70 mg/kg) reduces serum total cholesterol and LDL-cholesterol levels in Syrian golden hamsters fed a high-fat and high-cholesterol diet.3
1.Jung, H.A., Min, B.S., Yokozawa, T., et al.Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloidsBiol. Pharm. Bull.32(8)1433-1438(2009) 2.Chen, H.-Y., Ye, X.-L., Cui, X.-L., et al.Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cellsFitoterapia83(1)67-73(2012) 3.Zou, Z.-Y., Hu, Y.-R., Ma, H., et al.Epiberberine reduces serum cholesterol in diet-induced dyslipidemia Syrian golden hamsters via network pathways involving cholesterol metabolismEur. J. Pharmacol.774(2016)
动态评分
0.0