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  • Fostemsavir Tris
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Fostemsavir Tris

Fostemsavir Tris (BMS-663068 (Tris)) 是HIV-1附着抑制剂。

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  • 货号: ajce56386
  • CAS: 864953-39-9
  • 别名: BMS-663068 Tris
  • 分子式: C29H37N8O11P
  • 分子量: 704.62
  • 纯度: >98%
  • 溶解度: DMSO: 125 mg/mL (177.40 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Fostemsavir Tris (BMS-663068 (Tris)) is the phosphonooxymethyl prodrug of BMS-626529. Fostemsavir Tris (BMS-663068 (Tris)) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells. HIV-1[1]


Fostemsavir Tris has good antiviral activity in subjects infected with virus shown to be susceptible (IC50, <100 nM) to the agent[1].


[1]. Nowicka-Sans B, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507.

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