A lignan with diverse biological activities
Gomisin J is a lignan that has been found in Schisandra chinensis and has diverse biological activities.1,2 It inhibits HIV-1 IIIB replication in H9 T cells (EC50 = 1.5 ?g/ml).1 Gomisin J (20 ?M) decreases LPS-induced increases in nitric oxide (NO) production and p38, ERK, and JNK phosphorylation in RAW 264.7 cells.2 It induces relaxation of isolated, precontracted endothelium-intact rat aortic rings when used at concentrations of 3, 10, and 30 ?g/ml.3 Gomisin J is cytotoxic to 13 cancer cell lines, including breast, colon, and cervical cancer cells, when used at a concentration of 30 ?g/ml.4
1.Chen, D.-F., Zhang, S.-X., Xie, J.-X., et al.Anti-AIDS agents—XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analoguesBioorg. Med. Chem.5(8)1715-1723(1997) 2.Oh, S.-Y., Kim, Y.H., Bae, D.S., et al.Anti-inflammatory effects of gomisin J, and Schisandrin C isolated from the fruit of Schisandra chinensisBiosci. Biotechnol. Biochem.74(2)285-291(2010) 3.Park, J.Y., Hoi, Y.W., Yun, J.W., et al.Gomisin J from Schisandra chinensis induces vascular relaxation via activation of endothelial nitric oxide synthaseVascul. Pharmacol.57(2-4)124-130(2012) 4.Jung, S., Moon, H.-I., Kim, S., et al.Anticancer activity of gomisin J from Schisandra chinensis fruitOncol. Rep.41(1)711-717(2019)
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