Hypocrellin A

A perylenequinoid with diverse biological activities

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥1625.00

1300.00

- +
10mg

￥2612.00

2090.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajce56806
CAS: 77029-83-5
别名: 竹红菌甲素
分子式: C30H26O10
分子量: 546.52
纯度: >98%
溶解度: DMF: 2mg/mL,DMSO: 3mg/mL,Ethanol: 0.3mg/mL
储存: 4°C, protect from light
库存: 现货

Background

Hypocrellin A is a perylenequinoid that has been found in Shiraia bambusicola and has diverse biological activities.^1,2 It is active against C. albicans, C. parapsilosis, and C. tropicalis fungi (IC₅₀s = 0.65, 1, and 85 ?g/ml, respectively), as well as S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and M. intracellulare bacteria (IC₅₀s = 3, 7, 10, and 2.5 ?g/ml, respectively).¹ Hypocrellin A is also active against L. donovani promastigotes (IC₅₀ = 0.27 ?g/ml). Upon photoactivation with UV radiation, hypocrellin A induces production of reactive oxygen species and apoptosis and reduces cell viability of A549 cancer cells.²

1.Ma, G., Khan, S.I., Jacob, M.R., et al.Antimicrobial and antileishmanial activities of hypocrellins A and BAntimicrob. Agents Chemother.48(11)4450-4452(2004) 2.Qi, S., Guo, L., Yan, S., et al.Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathwayActa Pharm. Sin. B.9(2)279-293(2019)