A fungal metabolite
Hypocrellin B is a fungal metabolite that has been found in H. bambuase and has anticancer and antibacterial activities.1,2 It acts as a sonosensitizer, decreasing the viability of MDA-MB-231 breast cancer cells and inducing apoptosis in the presence of ultrasound exposure, effects that can be inhibited by the caspase inhibitor z-VAD-FMK.1 It also increases the production of reactive oxygen species (ROS) in MDA-MB-231 cells when used at a concentration of 2.5 ?M with concomitant ultrasound exposure. Hypocrellin B (20 ?M), in combination with ultrasound sonication, is active against methicillin-resistant S. aureus (MRSA).2
1.Jia, Y., Wang, X., Liu, Q., et al.Sonodynamic action of hypocrellin B triggers cell apoptoisis of breast cancer cells involving caspase pathwayUltrasonics73154-161(2017) 2.Leung, A.W.N., Ip, M., Xu, C.S., et al.Sonodynamic bactericidal efficacy of hypocrellin A and B against methicillin-resistant Staphylococcus aureusHong Kong Med. J.23 Suppl 5(4)36-37(2017)
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