Idalopirdine

A 5-HT6 receptor antagonist

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库存: 现货

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2mg

￥1750.00

1400.00

- +
5mg

￥2625.00

2100.00

- +
10mg

￥3400.00

2720.00

- +
50mg

￥9087.00

7270.00

- +

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货号: ajce56824
CAS: 467459-31-0
别名: Lu AE58054
分子式: C20H19F5N2O
分子量: 398.37
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
储存: Store at -20°C
库存: 现货

Background

LU AE58054 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT₆ (K_i = 0.83 nM).¹ It is selective for 5-HT₆ over other 5-HT receptor subtypes (K_is = 250 to >10,000 nM) and 70 other targets but does bind to α_1A- and α_1B-adrenergic receptors (α_1B-ARs; K_is = 21 and 22 nM, respectively). LU AE58054 (5-20 mg/kg) reverses phencyclidine-induced deficits in novel object recognition memory in rats. When administered in combination with the cholinesterase inhibitor rivastigmine , LU AE58054 has an additive effect on the decreased number of slips and falls made by rats with bilateral striatal-dopaminergic and cortical-cholinergic system lesions, a model of Parkinson’s disease motor disruption, in the Michigan complex motor control task.²

1.Arnt, J., Bang-Andersen, B., Grayson, B., et al.Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in ratsInt. J. Neuropsychopharmacol.13(8)1021-1033(2010) 2.Cherian, A.K., Kucinski, A., Wu, R., et al.Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson's diseasePsychopharmacology (Berl)236(6)1701-1715(2019)