An inhibitor of microtubule assembly
Indibulin is an inhibitor of microtubule assembly.1 It destabilizes microtubules and is selective for immature neuronal and nonneuronal microtubules over mature neuronal microtubules.2 Indibulin is cytotoxic to a variety of cancer cells, including human SKOV3 ovarian, U87 glioblastoma, and AsPC-1 pancreatic cancer cells (IC50s = 36, 77, and 285 nM, respectively).1 It also induces complete tumor regression in a rat Yoshida AH13 sarcoma model when administered at a dose of 10 mg/kg without inducing systemic or neurotoxicity.
1.Bacher, G., Nickel, B., Emig, P., et al.D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicityCancer Res.61(1)392-399(2001) 2.Wienecke, A., and Bacher, G.Indibulin, a novel microtubule inhibitor, discriminates between mature neuronal and nonneuronal tubulinCancer Res.69(1)171-177(2009)
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