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  • Ixazomib citrate
Ixazomib citrate的可视化放大

Ixazomib citrate

Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ix

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Ixazomib citrate的二维码

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  • 货号: ajce56954
  • CAS: 1239908-20-3
  • 别名: 枸橼酸艾沙佐米; MLN9708
  • 分子式: C20H23BCl2N2O9
  • 分子量: 517.12
  • 纯度: >98%
  • 溶解度: DMSO: ≥ 100 mg/mL (193.38 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.


[1] Erik Kupperman, et al. Cancer Res. 2010 Mar 1;70(5):1970-80. [2] Edmund C Lee, et al. Clin Cancer Res . 2011 Dec 1;17(23):7313-23. [3] Gregory T.Notte. Annual Reports in Medicinal Chemistry. Volume 48, 2013, Pages 451-469.

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