- 客服:
- 电话: 13061953619
- 微信:
Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ix
Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.
[1] Erik Kupperman, et al. Cancer Res. 2010 Mar 1;70(5):1970-80. [2] Edmund C Lee, et al. Clin Cancer Res . 2011 Dec 1;17(23):7313-23. [3] Gregory T.Notte. Annual Reports in Medicinal Chemistry. Volume 48, 2013, Pages 451-469.
动态评分
0.0