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JAK3 covalent inhibitor-1 是一种 janus 激酶 3 (JAK3) 共价抑制剂,IC50 值为 11 nM,比其他的 JAK 激酶的选择性高 246 倍。
JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs[1]. JAK3|11 nM (IC50)
[1]. Casimiro-Garcia A, et al. Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. J Med Chem. 2018 Dec 13;61(23):10665-10699.
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