Kaurenoic acid

A diterpene with diverse biological activities

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库存: 现货

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1mg

￥362.00

290.00

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5mg

￥812.00

650.00

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10mg

￥1300.00

1040.00

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25mg

￥3187.00

2550.00

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货号: ajce57016
CAS: 6730-83-2
别名: 异贝壳杉烯酸；贝壳杉烯酸
分子式: C20H30O2
分子量: 302.45
纯度: >98%
溶解度: DMF: 10 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml,Ethanol: 10 mg/ml
储存: -20°C, protect from light
库存: 现货

Background

Kaurenoic acid is a diterpene that has been found in C. langsdorffii and has diverse biological activities, including anticancer, antibacterial, antioxidant, and anti-inflammatory properties.^1,2,3 It is cytotoxic to 22Rv1 and LNCaP prostate, HT-29, HCT116, SW480, and SW620 colon, and MCF-7 breast cancer cells with IC₅₀ values ranging from 15.03 to 48.87 μg/ml.² Kaurenoic acid is active against S. epidermidis, S. capitis, E. faecalis, and S. haemolyticus in vitro (MICs = 6.25-12.5 μg/ml).³ Kaurenoic acid (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in a rat model of acetic acid-induced colitis, as well as colonic tissue damage, leukocytic infiltration, and submucosal edema when administered at a dose of 100 mg/kg.¹

1.Paiva, L.A.F., Gurgel, L.A., Silva, R.M., et al.Anti-inflammatory effect of kaurenoic acid, a diterpene from Copaifera langsdorffi on acetic acid-induced colitis in ratsVascul. Pharmacol.39(6)303-307(2003) 2.Henry, G.E., Adams, L.S., Rosales, J.C., et al.Kaurene diterpenes from Laetia thamnia inhibit the growth of human cancer cells in vitroCancer Lett.244(2)190-194(2006) 3.Soares, A.C.F., Matos, P.M., Dias, H.J., et al.Variability of the antibacterial potential among analogue diterpenes against Gram-positive bacteria: Considerations on structure-activity subjectCan. J. Chem.97(7)568-575(2019)