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  • Lenvatinib mesylate
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Lenvatinib mesylate

An inhibitor of VEGFR2 and VEGFR3

原价
¥675-5625
价格
540-4500
Lenvatinib mesylate的二维码

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  • 货号: ajce57118
  • CAS: 857890-39-2
  • 别名: 仑伐替尼甲酸盐; E7080 mesylate
  • 分子式: C22H23ClN4O7S
  • 分子量: 522.96
  • 纯度: >98%
  • 溶解度: DMSO: 8.33 mg/mL (15.93 mM)
  • 储存: 4°C, protect from light
  • 库存: 现货

Background

Lenvatinib is an inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and VEGFR3 (IC50s = 4 and 5.2 nM, respectively).1,2 It also inhibits the related kinases VEGFR1, FGFR1, PDGFRα, PDGFRβ and KIT (IC50s = 22, 46, 51, 39, and 100 nM, respectively).1 Lenvatinib (30 mg/kg, twice per day) reduces tumor growth in an H146 small cell lung cancer mouse xenograft model and induces tumor regression when administered at a dose of 100 mg/kg twice per day. Formulations containing lenvatinib have been used in the treatment of differentiated thyroid cancer, renal cell carcinoma, and hepatocellular carcinoma.


1.Matsui, J., Yamamaoto, Y., Funahashi, Y., et al.E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibitionInt. J. Cancer122(3)664-671(2008) 2.Matsui, J., Funahashi, Y., Uenaka, T., et al.Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinaseClin. Cancer Res.14(17)5459-5465(2008)

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