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  • LOC14
LOC14的可视化放大

LOC14

A PDI inhibitor

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￥ 0-880
LOC14的二维码

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  • 库存: 现货
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  • 货号: ajce57188
  • CAS: 877963-94-5
  • 别名: 2-((4-(环丙烷羰基)哌嗪-1-基)甲基)苯并[D]异噻唑-3(2H)-酮
  • 分子式: C16H19N3O2S
  • 分子量: 317.41
  • 纯度: >98%
  • 溶解度: DMSO: 25 mg/mL (78.76 mM)
  • 储存: 4°C, protect from light ,unstable in solution, ready to use.
  • 库存: 现货

Background

LOC14 is an inhibitor of protein disulfide isomerase (PDI; Kd = 62 nM).1 It inhibits PDI chaperone activity in an insulin aggregation assay when used at a concentration of 75 ?M. LOC14 reduces PC12 cell death induced by the misfolded huntingtin protein mHTTQ103 (EC50 = 500 nM). It reduces medium spiny neuron (MSN) degeneration in a rat postnatal cortical brain slice model of mHTTQ73-induced Huntington’s disease.


1.Kaplan, A., Gaschler, M.M., Dunn, D.E., et al.Small molecule-induced oxidation of protein disulfide isomerase is neuroprotectiveProc. Natl. Acad. Sci. USA112(17)E2245-E2252(2015)

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