An internal standard for the quantification of losartan
Losartan-d4 is intended for use as an internal standard for the quantification of losartan (potassium salt) by GC- or LC-MS. Losartan is an antagonist of the angiotensin (AT) II receptor subtype AT1 with a Ki value of 5-20 nM.1 It has an attenuating effect on vein graft atherosclerosis in rabbits and effectively reduces arterial blood pressure in rats.2,3 Formulations containing losartan have been used to control hypertension while protecting renal function.4
1.Ji, H., Leung, M., Zhang, Y., et al.Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartanJ. Biol. Chem.269(24)16533-16536(1994) 2.Ge, J., Huang, D., Liang, C., et al.Upregulation of lectinlike oxidized low-density lipoprotein receptor-1 expression contributes to the vein graft atherosclerosis: Modulation by losartanAtherosclerosis177(2)263-268(2004) 3.Xavier, F.E., Rossoni, L.V., Alonso, M.J., et al.Ouabain-induced hypertension alters the participation of enothelial factors in α-adrenergic responses differently in rat resistance and conductance mesenteric arteriesBr. J. Pharmacol.143(1)215-225(2004) 4.Caruso, D., D'Avino, M., Acampora, C., et al.Effects of losartan and chlorthalidone on blood pressure and renal vascular resistance index in non-diabetic patients with essential hypertension and normal renal functionsJ. Cardiovasc. Pharmacol.44(5)520-524(2004)
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