A flavonoid glycoside with diverse biological activities
Luteolin 7-O-rutinoside is a polyketide-derived flavonoid glycoside that has been found in V. bugulifolium and has diverse biological activities.1,2,3 It scavenges DPPH radicals in a cell-free assay when used at concentrations ranging from 1 to 50 ?M.2 Luteolin 7-O-rutinoside is active against B. subtilis, S. aureus, A. tumefaciens, M. luteus, E. coli, and P. aeruginosa (MICs = 100-200 ?g/ml).3 It is also active against C. albicans, S. cerevisiae, and C. lusitaniae (MICs = 100, 200, and 50 ?g/ml, respectively) and the plant pathogenic fungus A. niger (MIC = 100 ?g/ml). Luteolin 7-O-rutinoside (57.6 ?g/animal) decreases hepatic and renal injury and increases survival in a mouse model of polyphosphate-induced lethal endotoxemia.4
1.Fraga, C.G.Plant Phenolics and Human Health: Biochemistry, Nutrition and PharmacologyThe Wiley-Iubmb series on biochemistry and molecular biology(2010) 2.Wang, W., Simon, J.E., Aviles, I.F., et al.Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.)J. Agric. Food Chem.51(3)601-608(2003) 3.Zhu, X., Zhang, H., and Lo, R.Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activitiesJ. Agric. Food Chem.52(25)7272-7278(2004) 4.Lee, I.-C., and Bae, J.-S.Anti-inflammatory effects of vicenin-2 and scolymoside on polyphosphate-mediated vascular inflammatory responsesInflamm. Res.65(3)203-212(2016)
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