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- 5-HT Receptor
- LY 344864 hydrochloride
LY 344864 hydrochloride
A 5-HT1F receptor antagonist
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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250mg￥0.000.00- +
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500mg￥0.000.00- +
- 货号: ajce57244
- CAS: 1217756-94-9
- 别名:
- 分子式: C21H23ClFN3O
- 分子量: 387.88
- 纯度: ＞98%
- 溶解度: DMF: 3mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL
- 储存: Store at -20°C
- 库存: 现货
Background
LY344864 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1F (Ki = 6 nM).1 It is selective for 5-HT1F over 5-HT1A-E , 5-HT2A-C, and 5-HT7 receptors (Kis = 0.53-4.85 ?M), as well as dopamine D1 and D2, GABAA, histamine H1, muscarinic, and α1-, α2-, and β-adrenergic receptors with Ki values ranging from 3.69 to greater than 100 ?M. LY344864 inhibits forskolin-induced cAMP accumulation in L-M(TK-) cells expressing recombinant human 5-HT1F receptors with an EC50 value of 3 nM. It decreases electrically stimulated extravasation of plasma proteins in the dura mater in a rat trigeminal nerve model of migraine headache (ID50s = 0.6 and 2.1 ng/kg for i.v. and oral administration, respectively).
1.Phebus, L.A., Johnson, K.W., Zgombick, J.M., et al.Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: Binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraineLife Sci.61(21)2117-2126(1997)
