MALT1 inhibitor MI-2

A MALT1 inhibitor

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥1212.00

970.00

- +
10mg

￥1575.00

1260.00

- +
50mg

￥5175.00

4140.00

- +
100mg

￥9287.00

7430.00

- +
200mg

￥0.00

0.00

- +
500mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajce57310
CAS: 1047953-91-2
别名: 2-氯-N-[4-[5-(3,4-二氯苯基)-3-(2-甲氧基乙氧基)-1H-1,2,4-三唑-1-基]苯基]乙酰胺
分子式: C19H17Cl3N4O3
分子量: 455.72
纯度: >98%
溶解度: DMSO: ≥ 46 mg/mL (100.94 mM)
储存: Store at -20°C
库存: 现货

Background

MI 2 is an inhibitor of the paracaspase MALT1 with an IC₅₀ value of 5.84 μM in a fluorescence assay.¹ It inhibits the growth of MALT1-dependent activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines (GI₅₀s = 0.2, 0.5, 0.4, and 0.4 μM for HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells, respectively). MI 2 inhibits cleavage of the MALT1 target protein CYLD in a dose-dependent manner in HBL-1 cells but does not inhibit caspase-3, caspase-8, and caspase-9, which are structurally similar to MALT1. MI 2 (25 mg/kg, i.v.) reduces tumor size in TMD8 and HBL-1 mouse xenograft models.

1.Fontan, L., Yang, C., Kabaleeswaran, V., et al.MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivoCancer Cell.22(6)812-824(2012)