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MC-Val-Cit-PAB-carfilzomib 是一种用于 ADC 的药物-接头偶联物,通过使用 carfilzomib(一种不可逆的蛋白酶体抑制剂),通过 ADC 接头 MC-Val-Cit-PAB 连接,具有有效的抗肿瘤活性。
MC-Val-Cit-PAB-carfilzomib has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Val-Cit-PAB-carfilzomib is used for the antibody-drug conjugates (ADC) that are effective and stable in vitro and in vivo to treat various diseases or disorders[1].
[1]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.
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