MS049

A selective, dual PRMT4/PRMT6 inhibitor

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库存: 现货

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包装

价格

促销价

数量
5mg

￥712.00

570.00

- +
10mg

￥1212.00

970.00

- +
25mg

￥2612.00

2090.00

- +
50mg

￥4750.00

3800.00

- +
100mg

￥8637.00

6910.00

- +
200mg

￥0.00

0.00

- +
500mg

￥0.00

0.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

MS049 is a potent and selective inhibitor of PRMT4 (IC₅₀ = 34 nM) and PRMT6 (IC₅₀ = 43 nM).¹ It is less active against additional type I PRMTs (IC₅₀s = >130, >220, and 1.6 ?M for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases or nonepigenetic targets tested.¹ MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC₅₀ value of 0.97 ?M and also, unexpectedly, to reduce H4R3me2a in HEK293 cells.¹ For more information on MS049 please visit the Structural Genomics Consortium (SGC). The negative control, MS049N, for MS049 is also available exclusively through the SGC. You can submit a request to receive the negative control here.

1.Shen, Y., Szewczyk, M.M., Eram, M.S., et al.Discovery of a potent, selective, and cell-active dual inhibitor of protein arginine methyltransferase 4 and protein arginine methyltransferase 6J. Med. Chem.(2016)