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  • Nimustine hydrochloride
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Nimustine hydrochloride

A pyrimidine analog and nitrosourea alkylating agent

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0-3880
Nimustine hydrochloride的二维码

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  • 货号: ajce57728
  • CAS: 55661-38-6
  • 别名: 盐酸尼莫司汀,ACNU
  • 分子式: C9H14Cl2N6O2
  • 分子量: 309.15
  • 纯度: >98%
  • 溶解度: DMSO: 62.5 mg/mL (202.17 mM)
  • 储存: 4°C, protect from light
  • 库存: 现货

Background

Nimustine is a pyrimidine analog and nitrosourea alkylating agent with anticancer activity.1,2,3 It inhibits the growth of U-251MG and EA285 glioma cells when used at a concentration of 10 μg/ml.2 Nimustine (30 mg/kg) increases the median survival time in a Walker 256 carcinoma rat model of metastatic brain tumors.3


1.Heal, J.M., Fox, P.L., and Schein, P.S.A structure-activity study of seven new water soluble nitrosoureasBiochem. Pharmacol.28(8)1301-1306(1978) 2.Yoshida, J., Shibuya, N., Kobayashi, T., et al.Sensitivity to I-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2- chioroethyl)-3-nitrosourea hydrochloride (ACNU) of glioma cells in vivo and in vitroCancer50(3)410-418(1982) 3.Hasegawa, H., Shapiro, W.R., and Posner, J.B.Chemotherapy of experimental metastatic brain tumors in female Wistar ratsCancer Res.39(7 Pt 1)2691-2697(1979)

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