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Nav1.7-IN-2 是一种有效的 PI3K 抑制剂,IC50 为 10 nM,详细信息可参考专利文献US7998990B2 中的化合物 Example 8。
NVP-QAV-572 is a PI3K inhibitor extracted from patent US7998990B2, Compound Example 8, has an IC50 of 10 nM. PI3K|10 nM (IC50)
NVP-QAV-572 (Example 8) is useful in the treatment of conditions which are mediated by the activation of the Pi3 kinase enzymes, particularly inflammatory or allergic conditions[1].
[1]. Emma Budd, et al. 5-phenyl-thiazol-2-yl-urea derivatives and use as PI3 kinase inhibitors. US 7998990 B2.
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