Okanin
Okanin 是 Coreopsis tinctoria 的有效成分。Okanin 通过抑制 TLR4/NF-κB 信号通路减弱 LPS 诱导的小胶质细胞活化。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
1mg￥1188.00950.00- +
-
5mg￥1875.001500.00- +
- 货号: ajce57830
- CAS: 484-76-4
- 别名: 奥卡宁
- 分子式: C15H12O6
- 分子量: 288.25
- 纯度: ＞98%
- 溶解度: DMSO : 16.67 mg/mL (57.83 mM; Need ultrasonic)
- 储存: 4°C, protect from light
- 库存: 现货
Background
Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways[1]. TLR4 p65
Okanin significantly inhibits LPS-induced TLR4 expression in BV-2 cells. Okanin inhibits the translocation of the NF-κB p65 subunit from the cytosol to the nucleus. Okanin significantly suppresses LPS-induced iNOS expression and also inhibites IL-6 and TNF-α production and mRNA expression in LPS-stimulated BV-2 cells[1].
[1]. Hou Y, et al. Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways. Sci Rep. 2017 Apr 3;7:45705.
