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  • Parecoxib
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Parecoxib

A prodrug form of valdecoxib

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0-1740
Parecoxib的二维码

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  • 货号: ajce57946
  • CAS: 198470-84-7
  • 别名: 帕瑞昔布; SC 69124
  • 分子式: C19H18N2O4S
  • 分子量: 370.42
  • 纯度: >98%
  • 溶解度: DMSO: ≥ 50 mg/mL (134.98 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib .1 It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC50 value of 2.4 ?M in HEK293 cells.2 It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg).1


1.Talley, J.J., Bertenshaw, S.R., Brown, D.L., et al.N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administrationJ. Med. Chem.43(9)1661-1663(2000) 2.Schr?der, H., H?llt, V., and Becker, A.Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissueNeurochem. Int.58(1)9-13(2011)

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